Review on the Synthesis and Therapeutic Potential of Pyrido[2,3-d], [3,2-d], [3,4-d] and [4,3-d]pyrimidine Derivatives

Joana F. Campos (1) , Thierry Besson (2, 3) , Sabine Berteina-Raboin (1)

1 ICOA - Institut de Chimie Organique et Analytique
2 UNIROUEN - Université de Rouen Normandie
3 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse

The objective of this review is to list the structures composed of a pyridopyrimidine moiety which have shown a therapeutic interest or have already been approved for use as therapeutics. We consider all the synthetic protocols to prepare these pyridopyrimidine derivatives. The review is organized into four sections, successively pyrido[2,3-d]pyrimidines, pyrido[3,4-d]pyrimidines, pyrido[4,3-d]pyrimidines and pyrido[3,2-d]pyrimidines. For each compound we present the biological activity and the synthetic route reported. To produce this manuscript, the bibliographic research was done using Reaxys and Scifinder for each kind of pyridopyrimidine.

Domaines: Chimie organique

Joana F. Campos, Thierry Besson, Sabine Berteina-Raboin. Review on the Synthesis and Therapeutic Potential of Pyrido[2,3-d], [3,2-d], [3,4-d] and [4,3-d]pyrimidine Derivatives. Pharmaceuticals, 2022, 15 (3), pp.352. ⟨10.3390/ph15030352⟩. ⟨hal-03890845⟩