Modern Approaches to Synthetic Design of Chiral α-Tertiary Amines Based on Trifluoromethylcontaining Ketimines: A Review - Archive ouverte HAL Access content directly
Journal Articles Theoretical and Experimental Chemistry Year : 2022

Modern Approaches to Synthetic Design of Chiral α-Tertiary Amines Based on Trifluoromethylcontaining Ketimines: A Review

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Abstract

Enantioselective construction methods of chiral derivatives of α-tertiary amines using acyclic and cyclic trifluoromethylketimines are considered. The importance of a trifluoromethyl group in the structure of ketimine substrates for effective asymmetric addition of C-nucleophilic reagents in the presence of metal complex catalysts or organocatalysts is emphasized. The practical application of these chiral products in medicinal chemistry is covered.
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hal-03888786 , version 1 (07-12-2022)

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Volodymyr Sukach, V. Tkachuk, Isabelle Gillaizeau, Mykhailo Vovk. Modern Approaches to Synthetic Design of Chiral α-Tertiary Amines Based on Trifluoromethylcontaining Ketimines: A Review. Theoretical and Experimental Chemistry, 2022, 57 (6), pp.387-420. ⟨10.1007/s11237-022-09710-z⟩. ⟨hal-03888786⟩
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