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Journal articles
Conformationally restricted oxazolidin‐2‐one fused bicyclic iminosugars as potential glycosidase inhibitors
Abstract : The synthesis of fused bicyclic oxazolidin-2-one (OZO) iminosugars was achieved through a tandem Staudinger reduction/retro-Michael/intramolecular Michael addition from the corresponding OZO azidosugars. Those precursors, based on both aldopentofuranoses and ketofuranohexoses backbones, were obtained following alkylation and oxidation of the related oxazolidine-2-thione (OZT) azidosugars. Eight OZO based iminosugars were isolated in good yields and evaluated for their potency as glycosidases inhibitors, thus extending the family of known 1-Deoxynojirimycin (DNJ) bicyclic analogues.
https://hal-univ-orleans.archives-ouvertes.fr/hal-03478285
Contributor : Pierre Lafite Connect in order to contact the contributor
Submitted on : Monday, December 13, 2021 - 9:56:12 PM
Last modification on : Tuesday, January 4, 2022 - 6:09:41 AM
Contributor : Pierre Lafite Connect in order to contact the contributor
Submitted on : Monday, December 13, 2021 - 9:56:12 PM
Last modification on : Tuesday, January 4, 2022 - 6:09:41 AM