Laser synthesis: a solvent-free approach for the preparation of phenylthiazolo[5,4-b]pyridine derivatives

Rihab Jemili (1) , Joana F Campos (2) , Nicolas Dumuis (1) , Hervé Rabat (1) , Nadjib Semmar (1) , Sabine Berteina-Raboin (2)

1 GREMI - Groupe de recherches sur l'énergétique des milieux ionisés
2 ICOA - Institut de Chimie Organique et Analytique

We describe here a rapid and straightforward solvent-free method to access phenylthiazolo[5,4-b]pyridines using a Nd-YAG laser NANO-NY81-10 (l ¼ 355 nm, 10 Hz pulse frequency; 8 ns pulse duration). This newly presented method successfully brings several improvements to the laser assisted synthesis of N,Sheterocycles. We are able to provide a solvent-, metal-and base-free method with good yield and a substantial reduction in reaction time.

Domaines: Chimie organique

Rihab Jemili, Joana F Campos, Nicolas Dumuis, Hervé Rabat, Nadjib Semmar, et al.. Laser synthesis: a solvent-free approach for the preparation of phenylthiazolo[5,4-b]pyridine derivatives. RSC Advances, 2021, 11 (9), pp.5003 - 5007. ⟨10.1039/d0ra10094c⟩. ⟨hal-03403649⟩